The VisualSonics Vevo 2100 is a high-resolution small-animal ultrasound imaging system with axial resolution as low as 30 microns.

Through a partnership with the University of Arizona Cancer Center the TBIR offers access to Definiens Tissue Studio 4.2 for biomarker and morphological profiling in histological images. Tissue Studio is an easy to use, robust, and powerful tool to automatically detect regions of interest based on user-defined criteria. It can distinguish cells and sub-cellular objects within target regions, and determine morphology and expression profiles per individual cell or cell compartment. It is compatible with brightfield or immunofluorescence images and whole tissue slides or tissue microarrays. Tissue Studio is compatible with most major file formats including Aperio (.svs), Hamamatsu (.ndpi), Leica (.scn), Roche Ventana (.bif), Zeiss (.czi), and TIFF.

Through a partnership with the University of Arizona Cancer Center, the TBIR provides a Spectral Instruments Imaging Lago, which has powerful multi-modality imaging capabilities in an advanced, user-friendly system. The turn-key system offers bioluminescence and fluorescence imaging. The high performance 2048x2048 air-cooled CCD camera provides high sensitivity with low background noise for accurate quantitative analysis. The Lago has 14 excitation wavelengths ranging from 360-805 nm and 20 emission filters ranging from 490-870 nm. The system has a field-of-view ranging from 6x6 cm up to 25x25 cm. These dynamic filter combinations can support a wide range of applications ranging from well-plate imaging to small animal imaging. Bioluminescence imaging of reporter genes such as luciferase and green fluorescent protein are easily accomplished with this scanner, and imaging of exogenous fluorescent agents can also be performed. The Lago incorporates a heated imaging platform and built-in isoflurane gas anesthesia.

Through a partnership with the University of Arizona Cancer Center, the TBIR provides a Siemens Inveon micro-CT scanner, which is a variable zoom cone-beam X-ray CT system that can generate images with a spatial resolution as small as 20 microns over a field of view as large as 8.4 cm x 5.5 cm. The large field of view enables single-bed position imaging of an entire mouse as well as larger objects such as rats with bed-stitching. The fully shielded design has built-in anesthesia and optional physiological monitoring. The scanner is best at evaluating bone density, but it can also image soft tissues with the use of CT contrast agents. Physiological monitoring ensures viability of the animal during the scan, and respiratory & cardiac gating improves image quality of the heart and lungs.