ICEL research, education and collaboration activities between July 1, 2021 and May 1, 2023.
Research: The Imaging Cores - Electron is a unique full-service lab at the University of Arizona, providing access to advanced expertise in Biological Transmission Electron Microscopy (TEM) to support basic and translational research, from consultation to high-resolution imaging, data analysis and interpretation. The core facility house the FEI Tecnai G2 Spirit BT transmission electron microscope and several ultramicrotomes, enabling investigators the ultrastructural evaluation and analysis of biological and non-biological samples, serving the academy and industry.
Education: The core facility provides access to hands-on TEM instrument and ultramicrotomy training. From a total of 86 users, 54.35 % training and assisted use were provided to graduate students, postdoctoral fellow, research staff and faculty.
Grants: Two grants were supported.
Thota, L.N.R.; Rosales, J.L.; Placencia, I.; Zemskov, E.A.; Tonino, P.; Michael, A.N.; Black, S.M.; Chignalia, A.Z. The Pulmonary Endothelial Glycocalyx Modifications in Glypican 1 Knockout Mice Do Not Affect Lung Endothelial Function in Physiological Conditions.Int. J. Mol. Sci. 2023, 24(19), 14568. pdf
Makam S, Sétamou M, Alabi OJ, Day W, Cromey D, Nwugo C. Mitigation of Huanglongbing: Implications of a biologically-enhanced nutritional program on yield, pathogen localization and host gene expression profiles. Plant Dis. 2023 Jul 6. doi: 10.1094/PDIS-10-22-2336-RE. pdf
Roxas JL, Ramamurthy S, Cocchi K, Rutins I, Harishankar A, Agellon A, Wilbur JS, Sylejmani G, Vedantam G, Viswanathan VK. Enteropathogenic Escherichia coli regulates host-cell mitochondrial morphology. Gut Microbes. 2022 Jan-Dec;14(1):2143224. doi: 10.1080/19490976.2022.2143224. pdf
Lindqvist J, Kolb J, de Winter J, Tonino P, Hourani Z, Labeit S, Ottenheijm C, Granzier H. Removal of MuRF1 Increases Muscle Mass in Nemaline Myopathy Models, but Does Not Provide Functional Benefits. Int J Mol Sci. 2022 Jul 23;23(15):8113. doi: 10.3390/ijms23158113. pdf
Biquand A, Spinozzi S, Tonino P, Cosette J, Strom J, Elbeck Z, Knöll R, Granzier H, Lostal W, Richard I. Titin M-line insertion sequence 7 is required for proper cardiac function in mice. J Cell Sci. 2021 Sep 15;134(18):jcs258684. doi: 10.1242/jcs.258684. pdf