The Functional Genomics Core (FGC) works with investigators to perform all necessary assay optimization and validation. The FGC staff will translate your protocol into a high-throughput workflow on our liquid handling robots. Our team can perform your compound screen, work with your group to perform the screen, or train you to work independently on our systems. The primary limit on the throughput of the screen is the speed of the assay. Simple fluorescence based assays can be read on our CLARIOstar Plus microplate reader, while complex cell phenotyping can be performed on our Operetta CLS, binding assays can be run on our Octet RED384 BioLayer Interferometry (BLI) instrument.
The FGC is integrated with the Arizona Center for Drug Discovery (ACDD) providing resources for investigators conducting research in molecular biology to run live cell, biochemical and other assays. The ACDD, housed in the UArizona College of Pharmacy, creates the necessary infrastructure to bridge UArizona researchers with pharmaceutical partners to establish a collaborative environment to advance novel disease intervention findings beyond the laboratory setting. The ACDD works with scientists at the UArizona to develop and perform research projects in drug discovery. The ACDD also maintains compound libraries and provides assay design and optimization support.
For information or support on compound screening or drug discovery contact Christopher Penton (pentoncm@arizona.edu) with the Arizona Center for Drug Discovery
